At each level, we revisit the 3 key themes and select a few representative contributions from the literature to use as examples. We then link to small cell groups, larger groups, and tissues (right). As shown in Fig 1, we start with the subcellular level of biochemical signaling (left), and move up to single cell behavior (center). The paper is organized by size-scale and level of detail. The focus on the above set of 3 questions is, to our knowledge, unique to the current review. Some survey computational methods and others provide links to experiments. Many excellent reviews are already available, including. What is the relationship between models and experiments in the current literature on the subject?Īt each level, we consider these 3 questions in subsections with headings “Bridging scales,” “Levels of detail,” and “Links with experiments.” Like any other subdivision, this is to some extent arbitrary, as literature papers often span such categories.What level of detail is appropriate in a computational or mathematical model? What kinds of models are suitable for a given situation?.To what extent have models provided a way to bridge between the 3 levels of organization, from intracellular signaling, to single cell behavior, and to collective cell/tissue behavior?.Because the literature is vast and growing exponentially, we limit our review to several key themes and concentrate on 3 questions: We focus on the role of modeling and computational biology. Here, we survey the state of the field, emphasizing bridges that span scales: from molecular signaling to multicellular hierarchies. Mathematical and computational modeling have become more universally accepted, more closely integrated with experimental research, and more advanced in terms of methodology. Though originally descriptive, cell biology has emerged as a quantitative science over the same time span. Recent efforts aim to link single cell behavior to collective behavior of many cells and emergent dynamics of tissues. We continue to discover links between cell signaling and cell shape and function, in both normal and diseased cells. Regulation of motility by intracellular signaling networks was then deciphered in the late 1990s and through the 2000s. In the 1980s and 1990s, the basic machinery of eukaryotic cell motion and the role of the actin cytoskeleton were discovered and refined. Please send bug reports, feature requests, etc., to Dr.Over several decades, there has been great progress in our understanding of cell motility. Includes many CPT format files that are compatible with Panoply. Additional color tables and map overlays may be opened for a single session or added to your favorites library for continued use.įor even more scale color tables, J.J. Panoply requires that your computer have Java 11 (or later version) installed.īeginning with version 4.0, Panoply's "standard" selection of color tables and map overlays is built into the application. Export animations as MP4 video or as a collection of invididual frame images.
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